Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.23/575
Título: Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases
Autor: Pacheco, C
Morais, A
Rolo, R
Ferreira, L
Nabiço, R
Cunha, J
Palavras-chave: Doença Granulomatosa Crónica
Imunodeficiência de Variável Comum
Data: 2014
Editora: Sociedade Portuguesa de Pneumologia
Citação: Rev Port Pneumol. 2014 Jan 22. pii: S0873-2159(13)00159-1.
Resumo: INTRODUCTION: Chronic granulomatous disease associated with common variable immunodeficiency (GD-CVID), although well documented, is rare. Granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis. CLINICAL CASES: Case 1: A 39-year-old male patient with CVID, asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. GD-CVID was diagnosed by bone marrow biopsy. Progressive clinical and radiological improvement was obtained with corticotherapy. Case 2: A 38-year-old male patient with CVID, suffered from asthenia, anorexia, myalgia, lower limbs edemas, and dry cough. He had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. A spontaneous resolution was detected after 9 months of evolution. CONCLUSION: GD-CVID is rare and can mimetize other pathologies, namely, sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge.
Peer review: yes
URI: http://comum.rcaap.pt/handle/123456789/5690
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