Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.23/842
Título: Giant congenital melanocytic nevi and neurocutaneous melanosis
Autor: Araújo, C
Resende, C
Pardal, F
Brito, C
Palavras-chave: Melanose/congénito
Síndromes Neurocutâneas
Nevo Pigmentado
Data: 2015
Citação: Case Rep Med. 2015;2015:545603.
Resumo: Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient.
Peer review: yes
URI: http://hdl.handle.net/10400.23/842
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