Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.23/922
Título: Leg ulcer as a manifestation of eosinophilic vasculitis in a patient with hepatitis C virus infection, medicated with pegylated interferon/ribavirin.
Autor: Resende, C
Pereira, T
Ventura, F
Brito, C
Palavras-chave: Eosinofilia
Úlcera da Pele
Hepatitis C Crónica
Ribavirina
Interferon-alpha
Data: 2015
Citação: BMJ Case Rep. 2015 Jun 11;2015. pii: bcr2015209377.
Resumo: Cryoglobulinaemic vasculitis is a complication of hepatitis C virus (HCV) infection, responding to treatment with pegylated interferon (peg-IFN)/ribavirin (RIB), but vasculitis may first appear after treatment with peg-IFN/RIB. A 35-year-old man with HCV infection presented to our department with a 2-month history of a 3.3×3 cm ulcer localised on the right shin, with a regular border, on a violaceous base. Histopathological examination revealed a leucocytoclastic vasculitis, rich in eosinophils. The patient had been treated with peg-IFN/RIB 10 months prior and treatment was discontinued after 2 months because of the appearance of arthralgias and neuropathy. Laboratory investigations revealed positive cryoglobulins, elevation of rheumatoid factor and reduction of C4 after treatment with peg-IFN/RIB. Dressings with a hydrocellular foam were placed and after 2 months the ulcer resolved. We presented this case because of the rarity of development of a cryoglobulinaemic vasculitis in a patient with HCV infection, previously treated with peg-IFN/RIB.
Peer review: yes
URI: http://hdl.handle.net/10400.23/922
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