Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.23/932
Título: Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival
Autor: Martins, SF
Amorim, R
Coelho-Mota, S
Costa, L
Pardal, F
Mesquita-Rodrigues, A
Longatto-Filho, A
Palavras-chave: Neoplasias Colorrectais
Antigénio ki-67
Metástase Linfática
Data: 2015
Citação: Biomed Res Int. 2015;2015: 131685
Resumo: Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumour-associated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained by Ki-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.
Peer review: yes
URI: http://hdl.handle.net/10400.23/932
Aparece nas colecções:HB - CIR - Artigos
HB - AN PAT - Artigos

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