HB - MED INT - Artigos
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Browsing HB - MED INT - Artigos by Author "Ângela, C"
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- Meningite criptocócica em doentes com infecção VIH - análise retrospectiva dos casos seguidos no H.S.Marcos entre 1998 e 2004Publication . Ângela, C; Leal, D; Carvalho, A; Oliveira, N; Pimentel, T; Ferreira, MS
- Pulmonary Kaposi sarcoma and disseminated Mycobacterium genavense infection in an HIV-infected patientPublication . Tribuna, C; Ângela, C; Eira, I; Carvalho, AWe report a case of Kaposi sarcoma (KS) and disseminated infection by Mycobacterium genavense in a 40-year-old HIV-positive man with CD4+ T-cell count 5/µL. He presented with anorexia, diarrhoea, cachexia and multiple firm violaceous nodules distributed over the face, neck and upper and lower extremities. Biopsy of a skin nodule was performed, confirming KS. Immunoperoxidase staining for human herpesvirus 8 was strongly positive. Endoscopic examination revealed erosive duodenopathy. Multiple biopsy samples showed numerous acid-fast bacilli at direct microscopic examination. Real-time PCR (RT-PCR) identified M. genavense. A CT scan showed diffuse pulmonary infiltrates with a 'tree-in-bud' appearance, striking splenomegaly and abdominal lymphadenopathy. A bronchoscopy was performed, revealing typical Kaposi's lesions in the upper respiratory tract. RT-PCR of bronchial aspirate identified M. genavense and Pneumocystis jirovecii. Despite treatment with highly active antiretroviral therapy, antimycobacterial therapy and trimethoprim/sulfamethoxazole, the outcome was fatal.