Browsing by Author "Carvalho, A"
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- Annual costs of chronic hepatitis B disease states in PortugalPublication . Raluy, M; De Cock, E; Tato-Marinho, R; Areias, J; Calinas, F; Carvalho, A; Matos, L; Rodrigues, B; Macedo, G; Velosa, J; Perelman, J
- Associação entre a mortalidade e a admissão na Medicina Interna ao fim-de-semanaPublication . Tribuna, C; Apolinário, I; Carvalho, A; Ângela, C; Gonçalves, FN
- Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countriesPublication . Araújo, PM; Carvalho, A; Pingarilho, M; Abecasis, AB; Osório, NSHIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 closely related database sequences. 80% of the A1 Portuguese isolates gathered in a main phylogenetic clade (MA1). Six transmission clusters were identified in MA1, encompassing isolates from Portugal, Spain, France, and United Kingdom. The most common transmission route identified was men who have sex with men. The origin of the MA1 was linked to Greece, with the first introduction to Portugal dating back to 1996 (95% HPD: 1993.6-1999.2). Individuals infected with MA1 virus revealed lower viral loads and higher CD4+ T-cell counts in comparison with those infected by subtype B. The expanding A1 clusters in Portugal are connected to other European countries and share a recent common ancestor with the Greek A1 outbreak. The recent expansion of this HIV-1 subtype might be related to a slower disease progression leading to a population level delay in its diagnostic.
- Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical PracticePublication . Velosa, J; Serejo, F; Bana, T; Redondo, I; Simão, A; Vale, AM; Pires, S; Macedo, G; Marinho, R; Peixe, P; Sarmento, J; Matos, L; Calinas, F; Carvalho, A; Figueiredo, AFrom 1907 patients with chronic hepatitis C proposed for treatment, we analysed 1380 (1124 naive and 256 treatment-experienced) with complete follow-up. Genotype and HCV RNA quantification were assayed by commercial tests. Viremia was considered high if >800,000IU/mL, and low if <400,000IU/mL. Liver fibrosis was staged in 614 patients. RESULTS: Genotype 1 was the most frequent (60%), followed by 3 (25%), 4 (9%) and 2 (2%); 3.2% had other or unclassified genotype. Genotype 1 was more prevalent in central Portugal and genotype 4 in the south. Viremia was =800,000IU/mL in 54.6% and <400,000IU/mL in 34.6% of the patients, particularly in genotype 2 (p<0.03) and 4 (p<0.001). Genotype non-1 had a significantly lower viral load (p=0.004). Mild or moderate fibrosis was present in 71.7% and bridging fibrosis or cirrhosis in 28.3%, with no differences among genotypes. Treatment was discontinued in 19.8%. SVR was achieved in 55.3% of naive and 36.3% of re-treated patients. CONCLUSIONS: Standard treatment of chronic hepatitis C in real-life achieves similar results obtained in clinical trials, despite differences of demographic and viral parameters.
- Complicação Rara Após Gastrectomia TotalPublication . Ribas, S; Gomes; Pereira, R; Carvalho, A
- Divertículo de Meckel perfurado por palito: relato de um caso clínicoPublication . Goulart, A; Pereira, R; Leão, P; Gomes, C; Carvalho, A
- Divertículo de Meckel perfurado por palito: relato de um caso clínicoPublication . Goulart, A; Pereira, R; Leão, P; Gomes, C; Carvalho, A
- Estudo de agentes microbiológicos na patologia respiratória aguda de doentes internados num serviço de MedicinaPublication . Pacheco, C; Silva, I; Carvalho, A; Antunes, R
- Hipotiroidismo Subclínico no IdosoPublication . Macedo Silva, S; Carvalho, A; Lopes-Pereira, M; Fernandes, VSubclinical hypothyroidism, defined as an increase of thyroid stimulating hormone levels with normal levels of thyroid hormones, could have a multiorgan impact. There seem to be differences in the elderly (over 65 years of age) which indicate that there should be a different approach in terms of diagnosis and the treatment.
- Meningite criptocócica em doentes com infecção VIH - análise retrospectiva dos casos seguidos no H.S.Marcos entre 1998 e 2004Publication . Ângela, C; Leal, D; Carvalho, A; Oliveira, N; Pimentel, T; Ferreira, MS