Browsing by Author "Marques, O"
Now showing 1 - 10 of 48
Results Per Page
Sort Options
- 20-year retrospective study of clinically non-functioning pituitary adenomas - a single center experiencePublication . Matta-Coelho, C; Ramos, R; Almeida, R; Marques, O
- Abordagem terapêutica e taxas de remissão na acromegalia – um estudo retrospetivoPublication . Monteiro, AM; Almeida, R; Marques, O
- Caracterização das doentes com cancro da mama no Hospital de Braga: utilização de trastuzumabPublication . Sousa, D; Marques, O; Almeida, R
- Cardiovascular safety of type 2 diabetes medications: Review of existing literature and clinical implicationsPublication . Paredes, S; Matta-Coelho, C; Monteiro, AM; Brás, A; Marques, O; Alves, M; Ribeiro, LType 2 diabetes mellitus (T2DM), cardiovascular disease (CVD) and the cardiovascular effect of antidiabetic drugs are today critical medical issues, with the prevalence of T2DM in particular showing a steep increase worldwide, mainly due to unhealthy lifestyle habits. T2DM in association with obesity and other cardiovascular risk factors, results in the development of CVD, the leading cause of morbidity and mortality in patients with T2DM. Thus, treatment of T2DM is an individualized and complex challenge in which targeting cardiovascular risk factors is an important component in the decision making. Given the cardiovascular adverse events associated with rosiglitazone, both the Food and Drug Administration and the European Medicines Agency currently require the demonstration of cardiovascular safety of new antidiabetic drugs. Consequently, clinical trials to guarantee their cardiovascular safety are now obligatory. This review aims to summarize the available evidence on the cardiovascular effects and safety of the major drugs used in T2DM treatment and also to provide an overview of upcoming and ongoing clinical trials in this field. Our belief is that this review will be of substantial assistance to all medical doctors who are treating diabetic patients, namely primary care physicians, internal medicine doctors, endocrinologists, diabetologists and less well experienced personnel such as young doctors in training.
- A case of systemic pseudohypoaldosteronism with a novel mutation in the SCNN1A genePublication . Silva, N; Costa, M; Silva, A; Sá, C; Martins, S; Antunes, A; Marques, O; Castedo, S; Pereira, AWe report a neonatal case of systemic pseudohypoaldosteronism type 1 caused by a novel mutation in the SCNN1A gene (homozygous c.1052+2dupT in intron 3) in which the patient presented with life-threatening hyperkalemia, hyponatremia and metabolic acidosis. It remains uncertain if there is genotype-phenotype correlation, due to the rarity of the disease. This mutation, which to our best knowledge has not been described before, was associated with a very severe phenotype requiring aggressive therapy.
- Clinical and histological differences of papillary thyroid carcinoma in patients with chronic lymphocytic thyroiditisPublication . Monteiro, AM; Fernandes, V; Souto, S; Marques, O; Alves, M
- Colorectal cancer polyp screening in treated acromegalic patientsPublication . Lopes, S; Soares, JB; Marques, O; Almeida, R; Macedo, G
- Défice de vitamina D – um problema esquecido?Publication . Santos, MJ; Marques, O
- Descompensação metabólica da diabetes e tempestade tiroideia –causa ou consequência?Publication . Monteiro, AM; Matta-Coelho, C; Marques, O
- Diabetes e cirurgia de ambulatório – protocolo de atuação no período perioperatórioPublication . Monteiro, AM; Alves, M; Marques, OA diabetes mellitus é uma doença crónica de elevada prevalência em todo o mundo. Dado que os procedimentos cirúrgicos em regime de ambulatório têm aumentado significativamente, surge a necessidade de elaboração de um protocolo para o controlo glicémico destes doentes neste contexto. A avaliação cuidadosa pré‐operatória é fundamental e permite antecipar alterações no controlo glicémico e evitar complicações perioperatórias. Existe evidência crescente de que a otimização do controlo glicémico no período perioperatório se associa a diminuição da morbilidade e mortalidade. Com este artigo pretende‐se divulgar um protocolo atualizado, como proposta de atuação no controlo glicémico de pessoas com diabetes submetidas a procedimentos cirúrgicos em unidades de ambulatório. Abstract Diabetes mellitus is a chronic disease highly prevalent throughout the world. Since outpatient surgical procedures have significantly increased, there is a need to formulate a protocol for glycemic control of these patients in this context. Careful preoperative evaluation is crucial and allows us to anticipate changes in glycemic control and avoid perioperative complications. There is growing evidence that the optimization of glycemic control in the perioperative period is associated with decreased morbidity and mortality. With this article we intend to publish an updated protocol as an acting proposal on glycemic control in diabetic patients undergoing surgical procedures in outpatient units.