Browsing by Author "Ribeiro, M"
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- Abcesso isolado do clivus achados em ressonância magnética convencional: estudo de difusãoPublication . Fernandes, JS; Valle, JM; Morais, N; Ribeiro, M; Magalhães, Z; Moreira da Costa, JA; Rocha, J
- Alcohol abuse and acute behavioural disturbances in a 24-year-old patient. Diagnosis: Marchiafava-Bignami disease (MBD)Publication . Machado, A; Soares-Fernandes, J; Ribeiro, M; Rodrigues, M; Cerqueira, J; Ferreira, C
- Angioplastia CarotídeaPublication . Ribeiro, M; Xavier, J; Ferreira, C; Fernandes, J; Magalhães, Z; Rocha, J
- AVC isquémico sem hora de início conhecida: calçada para tratarPublication . Vilela de Oliveira, J; Abreu, J; Pinho, J; Rodrigues, M; Ribeiro, M; Rocha, J; Ferreira
- Clinical, imagiological and etiological spectrum of posterior reversible encephalopathy syndromePublication . Pereira, PR; Pinho, J; Rodrigues, M; Rocha, J; Sousa, F; Amorim, J; Ribeiro, M; Rocha, J; Ferreira, CObjective Analyze the cases of posterior reversible encephalopathy syndrome (PRES) admitted in a Neurology Department during an 8-year period. Method Retrospective observational study in a central hospital in the north of Portugal. Results 14 patients were identified, mean age 52.3 years. Precipitating factors included: eclampsia, isolated arterial hypertension, spinal trauma and autonomic dysreflexia, Guillain-Barré syndrome, sepsis, sarcoidosis and pulmonary cryptococcosis and drugs. Most patients presented posterior-predominant vasogenic edema lesions, however 64.2% presented frontal lesions and in 42.8% cerebellum was involved. Four patients also had acute ischemic lesions and 1 had hemorrhagic lesions. During follow-up 10 patients recovered fully, 2 recovered partially, 1 suffered a recurrence and 2 died in hospital. Conclusion PRES has many etiological factors. The terms posterior and reversible should be revised because PRES frequently involves other brain regions and it is not always reversible. PRES patients may develop life-threatening complications and mortality is not negligible.
- Cortical linear lesions in Wernicke's encephalopathy: can diffusion-weighted imaging herald prognostic information?Publication . Machado, A; Ribeiro, M; Soares-Fernandes, J; Cerqueira, J; Mare, R
- CSF Tau proteins reduce misdiagnosis of sporadic Creutzfeldt-Jakob disease suspected cases with inconclusive 14-3-3 resultPublication . Leitão, MJ; Baldeiras, I; Almeida, MR; Ribeiro, MH; Santos, AC; Ribeiro, M; Tomás, J; Rocha, S; Santana, I; Oliveira, CRCerebrospinal fluid (CSF) 14-3-3 protein supports sporadic Creutzfeldt-Jakob (sCJD) diagnosis, but often leads to weak-positive results and lacks standardization. In this study, we explored the added diagnostic value of Total Tau (t-Tau) and phosphorylated Tau (p-Tau) in sCJD diagnosis, particularly in the cases with inconclusive 14-3-3 result. 95 definite sCJD and 287 patients without prion disease (non-CJD) were included in this study. CSF samples were collected in routine clinical diagnosis and analysed for 14-3-3 detection by Western blot (WB). CSF t-Tau and p-Tau were quantified by commercial ELISA kits and PRNP and APOE genotyping assessed by PCR-RFLP. In a regression analysis of the whole cohort, 14-3-3 protein revealed an overall accuracy of 82 % (sensitivity = 96.7 %; specificity = 75.6 %) for sCJD. Regarding 14-3-3 clear positive results, we observed no added value either of t-Tau alone or p-Tau/t-Tau ratio in the model. On the other hand, considering 14-3-3 weak-positive cases, t-Tau protein increased the overall accuracy of 14-3-3 alone from 91 to 94 % and specificity from 74 to 93 % (p < 0.05), with no sensitivity improvement. However, inclusion of p-Tau/t-Tau ratio did not significantly improve the first model (p = 0.0595). Globally, t-Tau protein allowed a further discrimination of 65 % within 14-3-3 inconclusive results. Furthermore, PRNP MV genotype showed a trend to decrease 14-3-3 sensitivity (p = 0.051), but such effect was not seen on t-Tau protein. In light of these results, we suggest that t-Tau protein assay is of significant importance as a second marker in identifying 14-3-3 false-positive results among sCJD probable cases.
- Deficiência de desidrogenase do piruvato: achados em ressonância magnética neonatalPublication . Fernandes, JS; Gomes, R; Cruz, R; Ribeiro, M; Magalhães, Z; Rocha, J
- Diffuse large cell lymphoma, a different form of presentationPublication . Cabral, C; Lages, A; Gonçalves, A; Rocha, J; Amorim, JM; Ribeiro, M; Araújo, R; Gonçalves, F
- Diffusion-weighted MR imaging findings in an isolated abscess of the clivusPublication . Soares-Fernandes, JP; Valle-Folgueral, JM; Morais, N; Ribeiro, M; Moreira da Costa, JAWe report the finding of restricted diffusion in an isolated abscess of the clivus and discuss the imaging differential diagnosis, with an emphasis on the usefulness of diffusion-weighted imaging.