Browsing by Author "Souto, SB"
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- Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicityPublication . Fangueiro, JF; Andreani, T; Egea, MA; Garcia, ML; Souto, SB; Silva, AM; Souto, EBIn the present study we have developed lipid nanoparticle (LN) dispersions based on a multiple emulsion technique for encapsulation of hydrophilic drugs or/and proteins by a full factorial design. In order to increase ocular retention time and mucoadhesion by electrostatic attraction, a cationic lipid, namely cetyltrimethylammonium bromide (CTAB), was added in the lipid matrix of the optimal LN dispersion obtained from the factorial design. There are a limited number of studies reporting the ideal concentration of cationic agents in LN for drug delivery. This paper suggests that the choice of the concentration of a cationic agent is critical when formulating a safe and stable LN. CTAB was included in the lipid matrix of LN, testing four different concentrations (0.25%, 0.5%, 0.75%, or 1.0%wt) and how composition affects LN behavior regarding physical and chemical parameters, lipid crystallization and polymorphism, and stability of dispersion during storage. In order to develop a safe and compatible system for ocular delivery, CTAB-LN dispersions were exposed to Human retinoblastoma cell line Y-79. The toxicity testing of the CTAB-LN dispersions was a fundamental tool to find the best CTAB concentration for development of these cationic LN, which was found to be 0.5wt% of CTAB.
- Diabetes gestacional - a experiência do hospital de braga versus outros centros do registo nacional da diabetes gestacionalPublication . Matta-Coelho, C; Monteiro, AM; Lopes-Pereira, M; Souto, SB
- Hiperglicemia intermédiaPublication . Matta-Coelho, C; Souto, SB; Marques, O
- Hyperosmolar hyperglycaemic state and diabetic ketoacidosis – a 5 year retrospective study in a university hospitalPublication . Matta-Coelho, C; Nunes, C; Fernandes, V; Pinto, ML; Souto, SB; Marques, O
- Metabolically healthy obesity characterization and relation with vitamin D - study in a bariatric surgery populationPublication . Matta-Coelho, C; Fernandes, V; Monteiro, AM; Paredes, S; Multidisciplinary Group for Surgical Management of Obesity; Souto, SB; Correia, F
- Mucormicose rinocerebrorbitária e diabetes mellitus – a propósito de um caso clínico.Publication . Matta-Coelho, C; Amorim, J; Carvalho, SD; Silva, D; Monteiro, AM; Souto, SB; Marques, O
- Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney diseasePublication . Nogueira, C; Souto, SB; Vinha, E; Carvalho-Braga, D; Carvalho, DChronic kidney disease (CKD) represents a challenge in the treatment of type 2 diabetic patients. Renal impairment may affect drug clearance and other pharmacokinetic processes which can increase toxicity and drug to drug interactions or cause ineffective therapy. There are many oral glucose lowering drugs available for the treatment of type 2 diabetes mellitus (T2DM) with different mechanisms of action and different pharmacokinetic profiles. While all classes may be used in patients with mild renal impairment, therapeutic options for patients with moderate to severe CKD are still limited. This review focuses on the pharmacokinetics, metabolism, and safety of oral glucose lowering drugs in patients with T2DM and CKD.
- Primary hyperaldosteronism by Conn’s Syndrome – clinical case discussionPublication . Matta-Coelho, C; Monteiro, AM; Fernandes, V; Souto, SB; Manso, F; Marques, O
- Síndrome hiperosmolar hiperglicémica e cetoacidose diabética – estudo retrospectivo de 5 anos num hospital universitárioPublication . Matta-Coelho, C; Nunes, C; Fernandes, V; Pinto, ML; Souto, SB; Marques, O
- Turner syndrome, undiagnosed until adulthood.Publication . Matta-Coelho, C; Souto, SB; Marques, O