Publication
Ulcerative colitis in a Southern European country: a national perspective
| dc.contributor.author | Portela, F | |
| dc.contributor.author | Magro, F | |
| dc.contributor.author | Lago, P | |
| dc.contributor.author | Cotter, J | |
| dc.contributor.author | Cremers, I | |
| dc.contributor.author | Deus, J | |
| dc.contributor.author | Vieira, A | |
| dc.contributor.author | Lopes, H | |
| dc.contributor.author | Caldeira, P | |
| dc.contributor.author | Barros, L | |
| dc.contributor.author | Reis, J | |
| dc.contributor.author | Carvalho, L | |
| dc.contributor.author | Gonçalves, R | |
| dc.contributor.author | Campos, MJ | |
| dc.contributor.author | Ministro, P | |
| dc.contributor.author | Duarte, MA | |
| dc.contributor.author | Amil, J | |
| dc.contributor.author | Rodrigues, S | |
| dc.contributor.author | Azevedo, L | |
| dc.contributor.author | Costa-Pereira, A | |
| dc.date.accessioned | 2012-05-24T18:02:03Z | |
| dc.date.available | 2012-05-24T18:02:03Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | BACKGROUND: The incidence, prevalence, and even the clinical behavior of ulcerative colitis (UC) are highly variable in different world regions. In previous studies, Portugal was reported as having a milder clinical behavior. The aim of this study was to apply the Montreal Classification in a large group of UC Portuguese patients in order to describe their clinical characteristics and evaluate variables potentially useful for outcome prediction. METHODS: A cross-sectional study based on data collected from a nationwide online registry was undertaken. RESULTS: In all, 2863 patients with UC were included. Twenty-one percent had ulcerative proctitis, 52% left-sided colitis, and 28% extensive colitis. Sixty percent of patients had taken steroids, 14% immunosuppressors, 1% biologicals, and 4.5% were submitted to surgery. Patients with extensive colitis had more severe activity, needing more steroids, immunosuppressors, and surgery. At the time of diagnosis 61% were less than 40 years old and 5% less than 16. Younger patients also had a more aggressive initial course. Thirty-eight percent of patients had only taken salicylates during the disease course and were characterized by a lower incidence of systemic symptoms at presentation (3.8% versus 8.8%, P < 0.001), fewer extraintestinal manifestations (7.7% versus 24.0%, P < 0.001), and a higher prevalence of proctitis (32.1% versus 10.0%). CONCLUSIONS: A more aggressive phenotype was found in extensive colitis and in the initial course of younger patients, with an increased need for steroids and immunosuppressors. In addition, a significant percentage of patients, particularly with proctitis, showed a milder clinical evolution and were maintained in remission only with salicylates. | por |
| dc.identifier.citation | Inflamm Bowel Dis. 2010;16(5):822-9. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.23/249 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Wiley | por |
| dc.subject | Colite Ulcerosa | por |
| dc.title | Ulcerative colitis in a Southern European country: a national perspective | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |