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Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study.

dc.contributor.authorCicione, A
dc.contributor.authorDe Nunzio, C
dc.contributor.authorTubaro, A
dc.contributor.authorCantiello, F
dc.contributor.authorManno, S
dc.contributor.authorOliveira, C
dc.contributor.authorLima, E
dc.contributor.authorDamiano, R
dc.date.accessioned2016-02-15T21:27:59Z
dc.date.available2016-02-15T21:27:59Z
dc.date.issued2016
dc.description.abstractBACKGROUND: To test in multicenter setting if patients affected of metabolic syndrome (MetS) and initial widespread high grade prostatic intraepithelial neoplasia (wHGPIN) diagnosis are at higher risk of prostate cancer (PCa) on repeat biopsy. METHODS: Patients clinical charts from three European Academic Hospital were reviewed in order to identify patients with initial diagnosis of HGPIN undergone to repeat biopsy. Inclusion and exclusion criteria were adopted to minimize patient heterogeneity. MetS was defined according to Word Heart Organization criteria while initial wHGPIN when ≥4 cores biopsy were involved. A multivariate logistic model was computed to assess the association between PCa and clinical-pathological variables. RESULTS: Overall 283 patients were scheduled. Median age was 67 years (IQR 62-72). MetS was diagnosed in 116/283 (41 %) patients and PCa was detected in 84/283 (29.7 %) patients. In particular, PCa was more frequently diagnosed in patients affected of wHGPIN and MetS (45/86, 52.3 %) than in patients with wHGPIN and normal metabolic profile (28/95, 29.5 %), p = 0.002. The multivariate logistic model confirmed that wHGPIN and MetS are independent risk factors for following PCa diagnosis, respectively OR 2.4 (95 % CI 1.01-5.71, p = 0.04), OR 2.79 (95 % CI 1.49-5.22, p = 0.01) while total PSA and DRE findings are not able to predict PCa at repeat biopsy, OR 1.05 (95 % CI 0.98-1.03 p = 0.69) and OR 1.01 (95 % CI 0.55-1.84, p = 0.96) respectively. CONCLUSIONS: wHGPIN is positively associated to PCa; assessing metabolic profile and repeat prostate biopsy is advisable in patients with initial diagnosis of wHGPIN.pt_PT
dc.identifier.citationBMC Cancer. 2016 Feb 4;16(1):59.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.23/989
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectSíndrome Metabólicapt_PT
dc.subjectNeoplasia Prostática Intraepitelialpt_PT
dc.subjectNeoplasias da Próstatapt_PT
dc.subjectFactores de Riscopt_PT
dc.subjectBiópsiapt_PT
dc.titleMetabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study.pt_PT
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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