STATs in Lung Development: Distinct Early and Late Expression, Growth Modulation and Signaling Dysregulation in Congenital Diaphragmatic Hernia

Piairo, P; Moura, RS; Baptista, MJ; Correia-Pinto, J; Nogueira-Silva, C

http://hdl.handle.net/10400.23/1244

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Abstract(s)

Congenital diaphragmatic hernia (CDH) is a life-threatening developmental anomaly, intrinsically combining severe pulmonary hypoplasia and hypertension. During development, signal transducers and activators of transcription (STAT) are utilized to elicit cell growth, differentiation, and survival.