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Association between functional EGF+61 polymorphism and glioma risk

2007Journal article Open access
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dc.contributor.authorCosta, BM
dc.contributor.authorFerreira, P
dc.contributor.authorCosta, S
dc.contributor.authorCanedo, P
dc.contributor.authorOliveira, P
dc.contributor.authorSilva, AI
dc.contributor.authorPardal, F
dc.contributor.authorSuriano, G
dc.contributor.authorMachado, JC
dc.contributor.authorLopes, JM
dc.contributor.authorReis, RM
dc.date.accessioned2012-11-30T16:46:56Z
dc.date.available2012-11-30T16:46:56Z
dc.date.issued2007
dc.description.abstractPURPOSE: Epidermal growth factor (EGF) plays a critical role in cancer. A polymorphism in the EGF gene (EGF+61) may influence its expression and contribute to cancer predisposition and aggressiveness. In the present study, we aimed to elucidate the role of EGF+61 in glioma susceptibility and prognosis. EXPERIMENTAL DESIGN: A case-control study involving 197 glioma patients and 570 controls was done. Univariate and multivariate logistic regression analyses were used to calculate odds ratio (OR) and 95% confidence intervals (95% CI). False-positive report probability was also assessed. The luciferase reporter gene assay was used to ascertain the functional consequences of this polymorphism. RESULTS: Corroborating the univariate analysis, the multivariate model showed that the G allele conferred higher risks for gliomas (OR, 1.32; 95% CI, 1.04-1.67), glioblastomas (OR, 1.47; 95% CI, 1.02-2.10), and oligodendrogliomas (OR, 1.55; 95% CI, 1.07-2.23). The GG genotypes were associated with increased risk for gliomas (OR, 1.71; 95% CI, 1.07-2.73), glioblastomas (OR, 2.03; 95% CI, 1.02-4.05), and oligodendrogliomas (OR, 2.72; 95% CI, 1.18-6.28). In addition, the AG+GG genotypes were associated with higher risk for gliomas (OR, 1.52; 95% CI, 1.03-2.23) and oligodendrogliomas (OR, 2.80; 95% CI, 1.35-5.79). No significant association was observed between the EGF+61 polymorphism and glioblastoma or oligodendroglioma patients' overall survival. The luciferase reporter gene assay exhibited a significant increased promoter activity for the G variant compared with the reference A allele. CONCLUSIONS: These findings support the role of the EGF+61 polymorphism as a susceptibility factor for development of gliomas and show its implication on EGF promoter activity.por
dc.identifier.citationClin Cancer Res. 2007;13(9):2621-6.por
dc.identifier.urihttp://hdl.handle.net/10400.23/360
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationBRAIN TUMORS: MOLECULAR PROFILING AND ALTERATIONS RELATED TO THERAPY RESPONSE
dc.subjectGliomapor
dc.subjectPolimorfismo Genéticopor
dc.subjectPredisposição Genética para Doençapor
dc.subjectNeoplasias Cerebraispor
dc.titleAssociation between functional EGF+61 polymorphism and glioma riskpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBRAIN TUMORS: MOLECULAR PROFILING AND ALTERATIONS RELATED TO THERAPY RESPONSE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F15258%2F2004/PT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isProjectOfPublication43640382-5bd0-46fb-abba-d175e121cb52
relation.isProjectOfPublication.latestForDiscovery43640382-5bd0-46fb-abba-d175e121cb52

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