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Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practice

2011Journal article Open access
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dc.contributor.authorVelosa, J
dc.contributor.authorSerejo, F
dc.contributor.authorBana, T
dc.contributor.authorRedondo, I
dc.contributor.authorSimão, A
dc.contributor.authorVale, AM
dc.contributor.authorPires, S
dc.contributor.authorMacedo, G
dc.contributor.authorMarinho, R
dc.contributor.authorPeixe, P
dc.contributor.authorSarmento, J
dc.contributor.authorMatos, L
dc.contributor.authorCalinas, F
dc.contributor.authorCarvalho, A
dc.contributor.authorFigueiredo, A
dc.date.accessioned2013-11-15T15:33:17Z
dc.date.available2013-11-15T15:33:17Z
dc.date.issued2011
dc.description.abstractFrom 1907 patients with chronic hepatitis C proposed for treatment, we analysed 1380 (1124 naive and 256 treatment-experienced) with complete follow-up. Genotype and HCV RNA quantification were assayed by commercial tests. Viremia was considered high if >800,000IU/mL, and low if <400,000IU/mL. Liver fibrosis was staged in 614 patients. RESULTS: Genotype 1 was the most frequent (60%), followed by 3 (25%), 4 (9%) and 2 (2%); 3.2% had other or unclassified genotype. Genotype 1 was more prevalent in central Portugal and genotype 4 in the south. Viremia was =800,000IU/mL in 54.6% and <400,000IU/mL in 34.6% of the patients, particularly in genotype 2 (p<0.03) and 4 (p<0.001). Genotype non-1 had a significantly lower viral load (p=0.004). Mild or moderate fibrosis was present in 71.7% and bridging fibrosis or cirrhosis in 28.3%, with no differences among genotypes. Treatment was discontinued in 19.8%. SVR was achieved in 55.3% of naive and 36.3% of re-treated patients. CONCLUSIONS: Standard treatment of chronic hepatitis C in real-life achieves similar results obtained in clinical trials, despite differences of demographic and viral parameters.por
dc.identifier.citationHepatogastroenterology. 2011;58(109):1260-6por
dc.identifier.urihttp://hdl.handle.net/10400.23/549
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherUpdate Medical Publishingpor
dc.subjectHepaciviruspor
dc.subjectHepatitis C Crónicapor
dc.subjectInterferon-alphapor
dc.subjectRibavirinapor
dc.titleChronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical Practicepor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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