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Follicular thyroid carcinoma with an unusual glomeruloid pattern of growth.

2008Journal article Open access
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dc.contributor.authorCameselle-Teijeiro, J
dc.contributor.authorPardal, F
dc.contributor.authorEloy, C
dc.contributor.authorRuiz-Ponte, C
dc.contributor.authorCelestino, R
dc.contributor.authorCastro, P
dc.contributor.authorSoares, P
dc.contributor.authorSobrinho-Simões, M
dc.date.accessioned2013-06-21T13:47:19Z
dc.date.available2013-06-21T13:47:19Z
dc.date.issued2008
dc.description.abstractWe describe an uncommon thyroid tumor in a 56-year-old woman. The widely infiltrating, angioinvasive neoplasm, 5 cm in diameter, exhibited a peculiar architectural growth pattern characterized by follicles with round to oval epithelial tufts growing within, often supported by a fibrovascular core mimicking the renal glomerulus. Colloid-empty follicles, tubular or elongated, were lined by pseudostratified tall, columnar cells with clear cytoplasm. Nuclei were round to oval, with evenly distributed, slightly coarse chromatin. Tumor cells were positive for thyroid transcription factor-1, thyroperoxidase, thyroglobulin, cytokeratin 18, Hector Battifora mesothelial cell, and vimentin. Scattered cells positive for S100, Wilms tumor 1 (WT1), and cytokeratins AE1/AE3 were found, with no reaction detected for cytokeratins 34betaE12, 5/6, 7, 19, or 20. There were PAX8-PPARgamma rearrangement and N-RAS mutation. No mutations were found for APC or BRAF genes, nor were RET/PTC rearrangements detected. Because of the distinctive histologic features, we propose naming this tumor follicular thyroid carcinoma with an unusual glomeruloid pattern of growth.por
dc.identifier.citationHum Pathol. 2008;39(10):1540-7.por
dc.identifier.urihttp://hdl.handle.net/10400.23/450
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectAdenocarcinoma Folicularpor
dc.subjectMarcadores Tumorais Biológicospor
dc.subjectNeoplasias da Tiróidepor
dc.titleFollicular thyroid carcinoma with an unusual glomeruloid pattern of growth.por
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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