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Etiology of bronchiolitis in a hospitalized pediatric population: prospective multicenter study

2010Journal article Open access
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dc.contributor.authorAntunes, H
dc.contributor.authorRodrigues, H
dc.contributor.authorSilva, N
dc.contributor.authorFerreira, C
dc.contributor.authorCarvalho, F
dc.contributor.authorRamalho, H
dc.contributor.authorGonçalves, A
dc.contributor.authorBranca, F
dc.date.accessioned2012-01-16T18:58:49Z
dc.date.available2012-01-16T18:58:49Z
dc.date.issued2010
dc.description.abstractBACKGROUND: In 2006, bronchiolitis due to adenovirus nosocomial infections resulted in the closure of a pediatric department in northern Portugal. OBJECTIVES: To determine the etiology of bronchiolitis in northern Portugal. STUDY DESIGN: It was a prospective multicenter study on the etiology of bronchiolitis during the respiratory syncytial virus (RSV) season (November-April). Children < or = 24 months of age admitted for a first wheezing episode were included. Nasopharyngeal specimens were analyzed by an indirect immunofluorescent-antibody assay (IFA) for RSV, adenovirus (HAdV), parainfluenza (PIV) 1-3 and influenza (IV) A and B and by polymerase chain reaction (PCR) or reverse transcription-PCR for the same viruses and for human metapneumovirus (hMPV), bocavirus (HBoV), rhinovirus (HRV), coronaviruses (229/E; NL63; OC43; HKU1) and enterovirus. RESULTS: During this period, 253 children were included, 249 IFA analyses and 207 PCRs were performed. IFA detected RSV in 58.1%; PCR increased it to 66.7%. IFA detected HAdV in 3.2%, PCR 10.0%. PCR detected IV A in 5; IV B in 2; PIV 1 in 6, PIV 2 in 4 and PIV 3 in 11 cases. HBoV, as single agent in 2 cases, and HRV were positive in 8 samples and hMPV in 11. With this virus panel, 19.7% remained without etiology. CONCLUSIONS: The most frequent agent was RSV, followed by HAdV. PCR can be cost-effective and more accurate than IFA, which is crucial for HAdV that may be associated with significant mortality (IFA alone did not detect 2/3 of the cases).por
dc.identifier.citationJ Clin Virol. 2010;48(2):134-6.por
dc.identifier.urihttp://hdl.handle.net/10400.23/107
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectBronquiolitepor
dc.subjectHospitalizaçãopor
dc.subjectCriançapor
dc.titleEtiology of bronchiolitis in a hospitalized pediatric population: prospective multicenter studypor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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