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Fração Exalada de Óxido Nítrico no Controlo e Abordagem Terapêutica da Asma

2014Journal article Open access
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dc.contributor.authorMelo, B
dc.contributor.authorCosta, P
dc.contributor.authorAfonso, A
dc.contributor.authorMachado, V
dc.contributor.authorMoreira, C
dc.contributor.authorGonçalves, A
dc.contributor.authorGonçalves, JP
dc.date.accessioned2014-06-06T14:02:14Z
dc.date.available2014-06-06T14:02:14Z
dc.date.issued2014
dc.description.abstractINTRODUCTION: Asthma is a chronic respiratory disease characterized by hyper-responsiveness and bronchial inflammation. The bronchial inflammation in these patients can be monitored by measuring the fractional exhaled nitric oxide. This study aims to determine fractional exhaled nitric oxide association with peak expiratory flow and with asthma control inferred by the Global Initiative for Asthma. MATERIAL AND METHODS: Observational, analytical and cross-sectional study of children with asthma, 6-12 years-old, followed in the Outpatient Respiratory Pathology of Braga Hospital. Sociodemographic and clinical information were collected through a questionnaire. fractional exhaled nitric oxide and peak expiratory flow were determined by portable analyzer Niox Mino® and flow meter, respectively. RESULTS: The sample is constituted by 101 asthmatic children, 63 (62.4%) of males and 38 (37.6%) females. The mean age of participants in the sample is 9.18 (1.99) years. The logistic regression performed with the cutoff value obtained by ROC curve, revealed that fractional exhaled nitric oxide (b(FENO classes) = 0.85; χ(2)Wald (1) = 8.71; OR = 2.33; p = 0.003) has a statistical significant effect on the probability of changing level of asthma control. The odds ratio of going from "controlled" to "partly controlled/uncontrolled" is 2.33 per each level of fractional exhaled nitric oxide. DISCUSSION: The probability of an asthmatic children change their level of asthma control, from 'controlled' to 'partly controlled/uncontrolled', taking into account a change in their fractional exhaled nitric oxide level, increases 133%.por
dc.identifier.citationActa Med Port. 2014;27(1):59-66.por
dc.identifier.urihttp://hdl.handle.net/10400.23/616
dc.language.isoporpor
dc.peerreviewedyespor
dc.subjectCorticosteróidespor
dc.subjectAsmapor
dc.titleFração Exalada de Óxido Nítrico no Controlo e Abordagem Terapêutica da Asmapor
dc.title.alternativeFractional exhaled nitric oxide in monitoring and therapeutic management of asthmapor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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