Publication
The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer
| dc.contributor.author | Silva, IH | |
| dc.contributor.author | Nogueira-Silva, C | |
| dc.contributor.author | Figueiredo, T | |
| dc.contributor.author | Lombo, L | |
| dc.contributor.author | Faustino, I | |
| dc.contributor.author | Catarino, R | |
| dc.contributor.author | Nogueira, A | |
| dc.contributor.author | Pereira, D | |
| dc.contributor.author | Medeiros, R | |
| dc.date.accessioned | 2013-07-18T11:43:33Z | |
| dc.date.available | 2013-07-18T11:43:33Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | AIMS: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C>T polymorphism in treatment response in cervical cancer. METHODS: We retrospectively reviewed the clinical data of 167 patients with bulky cervical cancer submitted to cisplatin-based chemoradiotherapy. The genotypes of GGH -401C>T SNP were determined by real-time PCR and statistical analysis was performed by χ(2) test and survival analysis. RESULTS: The genotypes of GGH-401C>T were significantly associated with the response to platinum-based chemoradiotherapy. Treatment response was higher in patients carrying the CC genotype, who presented a significant increased chance of treatment response (survival time in months/genotype: 91 for CC Vs 72 for CT/TT; p=0.035, log rank test). A Cox regression analysis accordingly showed that the presence of the T allele was significantly linked to a worse treatment response (HR=3.036; CI 95% 1.032-8.934, p=0.044). CONCLUSIONS: The results of our study suggested the potential interest of GGH -401C>T as a predictive factor of the outcome of cervical carcinoma treated with cisplatin-based chemoradiotherapy. | por |
| dc.identifier.citation | Gene. 2013;512(2):247-50 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.23/462 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.subject | Quimiorradioterapia | por |
| dc.subject | Cisplatino | por |
| dc.subject | Polimorfismo de Nucleotídeo Único | por |
| dc.subject | Neoplasias do Colo do Útero | por |
| dc.subject | gama-Glutamil Hidrolase | por |
| dc.subject | Radiossensibilizantes | por |
| dc.title | The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |