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The dynamics of the stress neuromatrix

dc.contributor.authorSousa, N
dc.date.accessioned2016-05-04T11:34:35Z
dc.date.available2016-05-04T11:34:35Z
dc.date.issued2016-03
dc.description.abstractStressful stimuli in healthy subjects trigger activation of a consistent and reproducible set of brain regions; yet, the notion that there is a single and constant stress neuromatrix is not sustainable. Indeed, after chronic stress exposure there is activation of many brain regions outside that network. This suggests that there is a distinction between the acute and the chronic stress neuromatrix. Herein, a new working model is proposed to understand the shift between these networks. The understanding of the factors that modulate these networks and their interplay will allow for a more comprehensive and holistic perspective of how the brain shifts 'back and forth' from a healthy to a stressed pattern and, ultimately, how the latter can be a trigger for several neurological and psychiatric conditions.pt_PT
dc.identifier.citationMol Psychiatry. 2016 Mar;21(3):302-12.pt_PT
dc.identifier.doi10.1038/mp.2015.196pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.23/1018
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectCérebro/fisiologiapt_PT
dc.subjectStress Psicológicopt_PT
dc.titleThe dynamics of the stress neuromatrixpt_PT
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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