Publication
A comparison of microsatellite instability in early onset gastric carcinomas from relatively low and high incidence European populations.
| dc.contributor.author | Hayden, JD | |
| dc.contributor.author | Cawkwell, L | |
| dc.contributor.author | Dixon, MF | |
| dc.contributor.author | Pardal, F | |
| dc.contributor.author | Murgatroyd, H | |
| dc.contributor.author | Gray, S | |
| dc.contributor.author | Quirke, P | |
| dc.contributor.author | Martin, IG | |
| dc.date.accessioned | 2013-06-21T14:22:05Z | |
| dc.date.available | 2013-06-21T14:22:05Z | |
| dc.date.issued | 2000 | |
| dc.description.abstract | We have investigated the genetic basis of gastric carcinomas occurring in patients aged under 40 years from a Portuguese population with a relatively high incidence of gastric cancer. We analysed a panel of 12 microsatellite loci in DNA extracted from gastric carcinomas arising in 16 patients aged 24-39 years from Braga, Portugal. Overall, microsatellite instability (MI) in at least 1 locus was detected in 44% (7 of 16) of carcinomas. A single patient demonstrated a mutator phenotype suggestive of the hereditary nonpolyposis colorectal cancer syndrome with instability in 82% of loci. This carcinoma showed loss of expression of the hMLH1 mismatch repair protein. In a previous study, we found no evidence of MI among 10 cases of early onset gastric carcinomas from an English population, which has a relatively low incidence of gastric cancer. Comparing the 2 series, we found that there was a significant difference (p = 0.04) in the prevalence of MI (at least 1 marker affected). This geographical difference in low-level MI may be related to a significantly higher prevalence of background chronic atrophic gastritis (8 of 16 vs. 0 of 8) and Helicobacter pylori infection (15 of 16 vs. 2 of 8) in Portuguese carcinomas compared with English cases. Genetic mechanisms underlying the hereditary non-polyposis colorectal cancer syndrome may play a role in a small number of early onset gastric carcinomas. The difference in prevalence of low-level MI between these relatively high and low incidence European populations requires further investigation. | por |
| dc.identifier.citation | Int J Cancer. 2000;85(2):189-91. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.23/454 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Wiley | por |
| dc.subject | Repetições de Microssatélites | por |
| dc.subject | Neoplasias do Estômago | por |
| dc.title | A comparison of microsatellite instability in early onset gastric carcinomas from relatively low and high incidence European populations. | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |