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Mesalamine-induced myocarditis following diagnosis of Crohn's disease: a case report

2013Journal article Open access
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dc.contributor.authorGalvão-Braga, C
dc.contributor.authorMartins, J
dc.contributor.authorArantes, C
dc.contributor.authorRamos, V
dc.contributor.authorVieira, C
dc.contributor.authorSalgado, A
dc.contributor.authorMagalhães, S
dc.contributor.authorCorreia, A
dc.date.accessioned2014-02-14T15:30:35Z
dc.date.available2014-02-14T15:30:35Z
dc.date.issued2013
dc.description.abstractMesalamine is a common treatment for Crohn's disease, and can be rarely associated with myocarditis through a mechanism of drug hypersensitivity. We present the case of a 19-year-old male who developed chest pain two weeks after beginning mesalamine therapy. The electrocardiogram showed slight ST-segment elevation with upward concavity in the inferolateral leads; blood tests demonstrated elevated troponin I and the echocardiogram revealed moderately depressed left ventricular systolic function with global hypocontractility. Cardiac magnetic resonance imaging confirmed the diagnosis of myocarditis, revealing multiple areas of subepicardial fibrosis. The onset of symptoms after mesalamine, and improvement of chest pain, cardiac biomarkers and left ventricular systolic function after discontinuing the drug, suggest that our patient suffered from a rare drug-hypersensitivity reaction to mesalamine.por
dc.identifier.citationRev Port Cardiol. 2013;32(9):717-20.por
dc.identifier.urihttp://hdl.handle.net/10400.23/582
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSociedade Portuguesa de Cardiologiapor
dc.subjectDoença de Crohnpor
dc.subjectMiocarditepor
dc.subjectMesalaminapor
dc.titleMesalamine-induced myocarditis following diagnosis of Crohn's disease: a case reportpor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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