Publication
Ulcerative colitis in northern Portugal and Galicia in Spain
dc.contributor.author | Barreiro-da-Costa, M | |
dc.contributor.author | Magro, F | |
dc.contributor.author | Carpio, D | |
dc.contributor.author | Lago, P | |
dc.contributor.author | Echarri, A | |
dc.contributor.author | Cotter, J | |
dc.contributor.author | Pereira, S | |
dc.contributor.author | Gonçalves, R | |
dc.contributor.author | Lorenzo, A | |
dc.contributor.author | Carvalho, L | |
dc.contributor.author | Castro, J | |
dc.contributor.author | Barros, L | |
dc.contributor.author | Dias, JA | |
dc.contributor.author | Rodrigues, S | |
dc.contributor.author | Portela, F | |
dc.contributor.author | Dias, C | |
dc.contributor.author | Costa-Pereira, A | |
dc.date.accessioned | 2012-04-30T14:04:46Z | |
dc.date.available | 2012-04-30T14:04:46Z | |
dc.date.issued | 2010 | |
dc.description.abstract | BACKGROUND: Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC. METHODS: A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken. RESULTS: A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.001). The median age at diagnosis was 35 years and median years of disease was 7. The majority of patients (53%) were treated only with mesalamine, while 15% had taken immunosuppressant drugs, and 3% biologic treatment. Most patients in both groups were not at risk for aggressive therapy. Extensive colitis was a predictive risk factor for immunosuppression in northern Portugal and Galicia (odds ratio [OR] 2.737, 95% confidence interval [CI]: 1.846-4.058; OR 5.799, 95% CI: 3.433-9.795, respectively) and biologic treatment in Galicia (OR 6.329, 95% CI: 2.641-15.166). Younger patients presented a severe course at onset with more frequent use of immunosuppressors in both countries. CONCLUSIONS: In a large population of UC patients from two independent southern European countries, most patients did not require aggressive therapy, but extensive colitis was a clear risk factor for more severe disease | por |
dc.identifier.citation | Inflamm Bowel Dis. 2010;16(7):1227-38 | por |
dc.identifier.uri | http://hdl.handle.net/10400.23/223 | |
dc.language.iso | eng | por |
dc.peerreviewed | yes | por |
dc.publisher | Wiley | por |
dc.subject | Colite Ulcerosa | por |
dc.subject | Espanha | por |
dc.subject | Portugal | por |
dc.title | Ulcerative colitis in northern Portugal and Galicia in Spain | por |
dc.type | journal article | |
dspace.entity.type | Publication | |
rcaap.rights | openAccess | por |
rcaap.type | article | por |
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