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Ulcerative colitis in northern Portugal and Galicia in Spain

dc.contributor.authorBarreiro-da-Costa, M
dc.contributor.authorMagro, F
dc.contributor.authorCarpio, D
dc.contributor.authorLago, P
dc.contributor.authorEcharri, A
dc.contributor.authorCotter, J
dc.contributor.authorPereira, S
dc.contributor.authorGonçalves, R
dc.contributor.authorLorenzo, A
dc.contributor.authorCarvalho, L
dc.contributor.authorCastro, J
dc.contributor.authorBarros, L
dc.contributor.authorDias, JA
dc.contributor.authorRodrigues, S
dc.contributor.authorPortela, F
dc.contributor.authorDias, C
dc.contributor.authorCosta-Pereira, A
dc.date.accessioned2012-04-30T14:04:46Z
dc.date.available2012-04-30T14:04:46Z
dc.date.issued2010
dc.description.abstractBACKGROUND: Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC. METHODS: A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken. RESULTS: A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.001). The median age at diagnosis was 35 years and median years of disease was 7. The majority of patients (53%) were treated only with mesalamine, while 15% had taken immunosuppressant drugs, and 3% biologic treatment. Most patients in both groups were not at risk for aggressive therapy. Extensive colitis was a predictive risk factor for immunosuppression in northern Portugal and Galicia (odds ratio [OR] 2.737, 95% confidence interval [CI]: 1.846-4.058; OR 5.799, 95% CI: 3.433-9.795, respectively) and biologic treatment in Galicia (OR 6.329, 95% CI: 2.641-15.166). Younger patients presented a severe course at onset with more frequent use of immunosuppressors in both countries. CONCLUSIONS: In a large population of UC patients from two independent southern European countries, most patients did not require aggressive therapy, but extensive colitis was a clear risk factor for more severe diseasepor
dc.identifier.citationInflamm Bowel Dis. 2010;16(7):1227-38por
dc.identifier.urihttp://hdl.handle.net/10400.23/223
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.subjectColite Ulcerosapor
dc.subjectEspanhapor
dc.subjectPortugalpor
dc.titleUlcerative colitis in northern Portugal and Galicia in Spainpor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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