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Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma

dc.contributor.authorOliveira, LC
dc.contributor.authorFardilha, C
dc.contributor.authorLouro, M
dc.contributor.authorPinheiro, C
dc.contributor.authorSousa, A
dc.contributor.authorMarques, H
dc.contributor.authorCosta, P
dc.date.accessioned2019-03-01T11:11:59Z
dc.date.available2019-03-01T11:11:59Z
dc.date.issued2018
dc.description.abstractINTRODUCTION AND AIMS: Splenic marginal zone lymphoma, an uncommon subtype of non-Hodgkin lymphoma (NHL), is usually present with symptomatic splenomegaly. Although splenectomy has long been considered the first-line therapy in symptomatic or cytopenic patients, it can lead to significant morbidity and mortality. Splenic irradiation is an option for patients who have a poor response to systemic therapy and/or are not surgical candidates. In this paper, we present a case report of a patient who received splenic radiotherapy for symptomatic splenomegaly. METHODS: An 85-year-old Caucasian man with a 4 year history of low-grade NHL presented with progressive pancytopenia, significant weight loss and symptomatic splenomegaly (abdominal discomfort, sense of fullness and limitation of mobility due to spleen size). The patient refused splenectomy and, in December 2017, was referred to palliative splenic radiotherapy. He was initially treated with five fractions of one Grey (Gy) in order to evaluate clinical and haematology response. After that, 1.5 Gy daily, 5 days a week for 3 weeks. 3D conformal radiotherapy, multiple fields and mixed energy (6 and 15 Mv) were used. RESULTS: Radiotherapy allowed significant splenic reduction to almost half the size, resolving abdominal discomfort and improving quality of life. There was no decline of haemoglobin, leukocytes and platelet counts; in fact, there was a marginal increase. CONCLUSION: Palliative splenic irradiation was well tolerated confirming that it is a safe treatment option for palliation of symptomatic splenomegaly. Thereby, splenic irradiation should be strongly considered in the management of symptomatic splenomegaly, for selected patients who are refractory to or unsuitable for other options or when the patient refuses other treatments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEcancermedicalscience. 2018 Dec 13;12:887.pt_PT
dc.identifier.doi10.3332/ecancer.2018.887pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.23/1313
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectLinfoma Não-Hodgkinpt_PT
dc.subjectEsplenomegaliapt_PT
dc.titlePalliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage887pt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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