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Cerebral and cerebellar MRI volumes in Williams syndrome

2014-04Journal article Open access
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dc.contributor.authorOsório, A
dc.contributor.authorSoares, JM
dc.contributor.authorPrieto, MF
dc.contributor.authorVasconcelos, C
dc.contributor.authorFernandes, C
dc.contributor.authorSousa, SB
dc.contributor.authorCarracedo, A
dc.contributor.authorGonçalves, OF
dc.contributor.authorSampaio, A
dc.date.accessioned2016-05-04T13:22:13Z
dc.date.available2016-05-04T13:22:13Z
dc.date.issued2014-04
dc.description.abstractIndividuals with Williams syndrome (WS) present a set of cognitive, affective and motor symptoms that resemble those of patients with lesions to the cerebellum. Although there is some evidence for overall structural alterations in this brain region in WS, explorations on cerebellar white matter and cerebellar cortex volumes remain rather neglected. We aimed to compare absolute and relative cerebellar volumes, as well as patterns of white matter to cortex volumes in this brain region, between a group of individuals with WS and a group of healthy controls. T1-weighted magnetic resonance images were acquired in 17 individuals with WS and in 15 typically developing individuals. Our results showed that even though individuals from the clinical group had significantly smaller cerebrums (and cerebellums), cerebellar volumes relative to intracranial volumes were significantly enlarged. In addition, while gray matter was relatively spared and white matter disproportionately reduced in the cerebrum in WS, relative cerebellar cortex and white matter volumes were preserved. These findings support the hypothesis that volume alterations in the cerebellum are associated with the cognitive, affective and motor profiles in WS.pt_PT
dc.identifier.citationRes Dev Disabil. 2014 Apr;35(4):922-8.pt_PT
dc.identifier.doi10.1016/j.ridd.2013.12.014pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.23/1024
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectCórtex Cerebralpt_PT
dc.subjectCórtex Cerebelarpt_PT
dc.subjectRessonância Magnéticapt_PT
dc.subjectSíndrome de Williamspt_PT
dc.subjectFibras Nervosas Mielinizadaspt_PT
dc.subjectFibras Nervosas Amielínicaspt_PT
dc.titleCerebral and cerebellar MRI volumes in Williams syndromept_PT
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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