Browsing by Author "Rodrigues, M"
Now showing 1 - 10 of 32
Results Per Page
Sort Options
- Alcohol abuse and acute behavioural disturbances in a 24-year-old patient. Diagnosis: Marchiafava-Bignami disease (MBD)Publication . Machado, A; Soares-Fernandes, J; Ribeiro, M; Rodrigues, M; Cerqueira, J; Ferreira, C
- Androgenic alopecia: an entity to consider in adolescencePublication . Rodrigues, M; Antunes, I; Magalhães, S; Pereira, N
- AVC isquémico sem hora de início conhecida: calçada para tratarPublication . Vilela de Oliveira, J; Abreu, J; Pinho, J; Rodrigues, M; Ribeiro, M; Rocha, J; Ferreira
- Brain functional connectivity is altered in patients with Takotsubo SyndromePublication . Silva, AR; Magalhães, R; Arantes, C; Moreira, PS; Rodrigues, M; Marques, P; Marques, J; Sousa, N; Pereira, VHTakotsubo syndrome (TTS) is an acute, reversible cardiomyopathy. The central autonomic nervous system (ANS) is believed to play a role in this disease. The aim of the present study was to investigate the patterns of brain functional connectivity in a sample of patients who had experienced a previous episode of TTS. Brain functional connectivity, both at rest and in response to the stressful stimulus of topical cold stimulation, was explored using functional magnetic resonance imaging (fMRI), network-based statistics (NBS) and graph theory analysis (GTA) in a population consisting of eight patients with a previous episode of TTS and eight sex- and age-matched controls. At rest, a network characterized by increased connectivity in the TTS group compared to controls and comprising elements of the central ANS was identified. GTA revealed increased local efficiency, clustering and strength in regions of the bilateral hippocampus in subjects with a previous episode of TTS. When stressed by local exposure to cold, the TTS group differed significantly from both a pre-stress baseline interval and from the control group, showing increased connectivity in a network that included the left amygdala and the right insula. Based on the results, patients with TTS display a reorganization of cortical and subcortical networks, including areas associated with the emotional response and autonomic regulation. The findings tend to support the hypothesis that a deregulation of autonomic control at the central level plays a significant role in this syndrome.
- Clinical, imagiological and etiological spectrum of posterior reversible encephalopathy syndromePublication . Pereira, PR; Pinho, J; Rodrigues, M; Rocha, J; Sousa, F; Amorim, J; Ribeiro, M; Rocha, J; Ferreira, CObjective Analyze the cases of posterior reversible encephalopathy syndrome (PRES) admitted in a Neurology Department during an 8-year period. Method Retrospective observational study in a central hospital in the north of Portugal. Results 14 patients were identified, mean age 52.3 years. Precipitating factors included: eclampsia, isolated arterial hypertension, spinal trauma and autonomic dysreflexia, Guillain-Barré syndrome, sepsis, sarcoidosis and pulmonary cryptococcosis and drugs. Most patients presented posterior-predominant vasogenic edema lesions, however 64.2% presented frontal lesions and in 42.8% cerebellum was involved. Four patients also had acute ischemic lesions and 1 had hemorrhagic lesions. During follow-up 10 patients recovered fully, 2 recovered partially, 1 suffered a recurrence and 2 died in hospital. Conclusion PRES has many etiological factors. The terms posterior and reversible should be revised because PRES frequently involves other brain regions and it is not always reversible. PRES patients may develop life-threatening complications and mortality is not negligible.
- Deep cerebral venous thrombosis: a challenging diagnosisPublication . Pires, A; Rocha, S; Rodrigues, M; Machado, A; Lourenço, E; Ferreira, C
- Deep cerebral venous thrombosis: a challenging diagnosis.Publication . Pires, A; Rocha, S; Rodrigues, M; Machado, A; Lourenço, E; Ferreira, C
- Diversity in anti-N-methyl-D-aspartate receptor encephalitis: case-based evidencePublication . Pinho, J; Rocha, J; Rodrigues, M; Pereira, J; Maré, R; Ferreira, C; Lourenço, E; Beleza, PAntibodies against N-methyl-D-aspartate receptor (NMDAR) are identified in the form of immune-mediated encephalitis in which typical manifestations include neuropsychiatric symptoms, seizures, abnormal movements, dysautonomia and hypoventilation. The authors report two cases of anti-NMDAR encephalitis with different presentations and patterns of progression. The first patient presented with status epilepticus and later developed psychosis, pyramidal signs and diffuse encephalopathy. The second patient presented with acute psychosis followed a week later by seizures, dystonia, rigidity, oromandibular dyskinesias and dysautonomia. Possible mechanisms responsible for the clinical manifestations of this disease are discussed in light of recently described additional clinical and laboratory findings.
- Hypertrophic olivary degeneration and cerebrovascular disease: movement in a triangle.Publication . Santos, AF; Rocha, S; Varanda, S; Pinho, J; Rodrigues, M; Ramalho Fontes, J; Soares-Fernandes, J; Ferreira, CHypertrophic olivary degeneration is a rare kind of trans-synaptic degeneration that occurs after lesions of the dentatorubro-olivary pathway. The lesions, commonly unilateral, may result from hemorrhage due to vascular malformation, trauma, surgical intervention or hypertension, tumor, or ischemia. Bilateral cases are extremely rare. This condition is classically associated with development of palatal tremor, but clinical manifestations can include other involuntary movements. We describe 2 cases: unilateral hypertrophic olivary degeneration in a 60-year-old man with contralateral athetosis and neurologic worsening developing several years after a pontine hemorrhage and bilateral hypertrophic olivary degeneration in a 77-year-old woman with development of palatal tremor, probably secondary to pontine ischemic lesions (small vessel disease).
- Intravenous thrombolysis is more effective in ischemic cardioembolic strokes than in non-cardioembolic?Publication . Rocha, S; Pires, A; Gomes, J; Sousa, F; Pinho, J; Rodrigues, M; Ferreira, C; Machado, A; Maré, R; Fontes, JRIt was suggested that intravenous thrombolysis (IT) leads to larger extent recanalization in cardioembolic stroke. In this work we assess if this has beneficial clinical traduction. METHOD: We evaluated 177 patients undergoing IT, which were categorized into cardioembolic (CE) and non-cardioembolic (NCE). National Institutes of Health Stroke Scale (NIHSS) and modified Rankin scale were compared. RESULTS: The mean age was 67.4±12.01 and 53.8% were male. The mean NIHSS was: 14 (admission), 9 (24 h) and 6 (discharge), similar in subgroups. The difference between NIHSS at admission and 24 hours was 4.17±4.92 (CE: 4.08±4.71; NCE: 4.27±5.17, p=0.900) and at admission and discharge there was an average difference of 6.74±5.58 (CE: 6.97±5.68; NCE: 6.49±5.49, p=0.622). The mRS at discharge and 3 months was not significantly different by subtype, although individuals whose event was NCE are more independent at 3 months. CONCLUSION: Ours findings argue against a specific paper of IT in CE. It can result from heterogeneity of NCE group