Browsing by Issue Date, starting with "2005"
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- Dermatofitias no Distrito de Braga – Revisão de 22 AnosPublication . Pereira, T; Duarte, ML; Sousa-Basto, AAs infecções por dermatófitos são muito frequentes na prática clínica, observando-se diferenças epidemiológicas na etiologia dos agentes ao longo dos anos. Com o objectivo de avaliar a epidemiologia e etiologia das infecções causadas por dermatófitos no distrito de Braga, foi efectuado um estudo retrospectivo dos exames micológicos efectuados na Secção de Micologia do nosso Serviço, entre Janeiro de 1983 e Dezembro de 2004. Das 11.152 colheitas realizadas em doentes com suspeita clínica de infecção fúngica, foi identificada a presença de dermatófitos em 2.617 casos (23,5%). A infecção mais frequente foi a tinea corporis (39%), seguida da tinea capitis (21%) e da tinea pedis (19%). O Trichophyton rubrum foi a espécie predominante na tinea corporis (34,2%), na tinea manuum (54,4%), na tinea pedis (54,6%), na tinea unguium (72,2%) e na tinea cruris (75,0%). O Mycrosporum canis predominou na tinea capitis (70,7%) e o T. megninii na tinea barbae (28,9%). Globalmente, o agente etiológico mais frequentemente encontrado foi o Trichophyton rubrum, com 37,5% do total dos isolamentos e com incidência crescente ao longo de todo o período. Paralelamente observou-se uma diminuição acentuada da incidência do Trichophyton megnini. O T. mentagrophytes var. granulare teve uma incidência rapidamente crescente nos últimos 8 anos, tornando-se o segundo fungo mais frequentemente isolado.
- Mutation analysis of B-RAF gene in human gliomas.Publication . Basto, D; Trovisco, V; Lopes, JM; Martins, A; Pardal, F; Soares, P; Reis, RMThe RAS/RAF/MEK/ERK kinase pathway is pivotal in the transduction of mitogenic stimuli from activated growth factor receptors, which regulates cell proliferation, survival, and differentiation. Up-regulation of this pathway due to RAS mutations is found in approximately 30% of human tumors. Recently, activating mutations of B-RAF were identified in a large proportion of human cancers. Gliomas are the most frequent primary central nervous system tumors and the molecular mechanisms that underlie the development and progression of these tumors are far from being completely understood. The purpose of this study was to clarify the incidence of B-RAF mutations and their possible relation with tumor progression in a series of 82 human gliomas, including 49 astrocytic and 33 oligodendroglial tumors. The analysis of B-RAF hotspot regions, exons 11 and 15, showed presence of B-RAF mutations in only 2 out of 34 (6%) glioblastomas, and absence in the remaining histological types. Both mutations were located in the hotspot residue 600 (V600E) at exon 15, which leads to constitutive B-RAF kinase activity. These data suggest that activating mutations of B-RAF are not a frequent event in gliomas; nevertheless, when present they are associated with high-grade malignant lesions.
- Iron deficiency anemia in infants. Preliminary development results at five yearsPublication . Antunes, H; Gonçalves, S; Teixeira-Pinto, A; Costa-Pereira, A; Tojo-Sierra, R; Aguiar, AINTRODUCTION: Research, mostly conducted in developing countries, have suggested short and long term developmental delay in children who had iron-deficiency anemia (IDA) in their early life. This study aims to evaluate the development of 5-years old children who were diagnosed IDA at 9 months of age. METHODS: 27 children with IDA diagnosed at 9 months of age and 28 non-anemic controls were followed-up until they were 5 years old. At 9 months of age and at 5 years of age, blood samples were collected for blood count, iron, transferrin and ferritin. Children with hemoglobin < 110 g/l and ferritin < 12 ng/ml were diagnosed with IDA and received iron treatment for IDA correction. C Reactive Protein and antibody to hepatitis A virus were also studied at 5 years of age. At this age, children's motor and cognitive development were accessed using Griffith's test. RESULTS: At 9 months of age, IDA children had [mean (SD)] 102.5 g/ l (5.9) g/l of hemoglobin and 5.6 ng/l (3.1) ng/ml of ferritin. At 5 years of age all children were healthy and without anemia. One child had positive antibody to hepatitis A virus. The results of Griffith's test at five years--anemic/non-anemic at 9 months of age. The mean (sd)-p: general coefficient--100.8 (6.6)/99.5 (7.1)-0.48; locomotor 110.2 (6.9)/109.3 (6.5)-0.62; personal-social--99.1 (11.4)/95.7(11.6)-0.28; hearing-speech--93.8 (9.1)/95.3 (13.7)-0.64; hand-eye--98.2 (13.2)/99.1 (14.3)-0.79; performance--97.5 (17.6)/96.9 (13.6)-0.88; practical reasoning--89.8 (9.1)/86.3(7.1)-0.21. CONCLUSIONS: As only one child had positive antibody to hepatitis A virus, the study population may be considered as belonging to a developed region. These results suggest that, at least in developed regions, infants who receive an early treatment for their mild IDA may not be affected in global development at the age of five.
- Delay in hospital admission of patients with cerebral vein and dural sinus thrombosisPublication . Ferro, JM; Lopes, MG; Rosas, MJ; Fontes, J; VENOPORT InvestigatorsFactors influencing early hospital admission have been described for several stroke types but not for cerebral vein and dural sinus thrombosis (CVT). CVT is more difficult to diagnose than arterial stroke; delay in hospital admission may postpone CVT treatment. The purposes of this study were: (1) to describe the delay between the onset of symptoms and hospital admission of patients with CVT, and (2) to identify the variables that influence that delay. We registered the interval (days) between the onset of symptoms and hospital admission in 91 consecutive patients admitted to 20 Portuguese hospitals between June 1995 and June 1998. We also studied the impact of admission delay on treatments (prescription of anticoagulants and the number of days elapsed between the onset of symptoms and start of anticoagulation and admission). Median admission delay was 4 days. Twenty-two (25%) patients were admitted within 24 h. Two thirds of the patients were admitted within 7 days and 75% within 13 days. In multiple logistic regression analysis, admission within 24 h was positively associated with mental status disorder (delirium or abulia; OR = 4.59; 95% CI = 1.41-14.89) and negatively associated with headache (OR = 0.03; 95% CI = 0.00-0.32). Presentation as isolated intracranial hypertension was associated with admission delay of more than 4 days (OR = 2.63; 95% CI = 0.97-7.14). Papilloedema was associated with an admission delay of more than 13 days (OR = 4.69; 95% CI = 1.61-13.61). There was no association between admission delay and the proportion of anticoagulated patients. The interval between onset of symptoms and start of anticoagulation was shorter in patients admitted earlier (p = 0.0001, for either admission within 24 h, 4 or 13 days). There is a considerable delay until the clinical picture associated with CVT is recognised as justifying hospital admission, especially when patients present with symptoms identical to isolated intracranial hypertension syndrome.
- Squamous cell carcinoma in bladder extrophyPublication . Cabral-Ribeiro, J; Silva, C; Sousa, L; Pérez García, D; Ribeiro dos Santos, ABladder extrophy is a rare congenital malformation that nowadays is surgically corrected in neonatal period. We present a case report of a 71-year-old male with a verrucous squamous cell carcinoma arising in a classical uncorrected form of bladder extrophy.
- Renal cancer presenting thrombus of the vena cava reaching the right atrium. NMR imagesPublication . Cabral-Ribeiro, J; Braz Silva, C; Cerqueira Alves, M; Sousa, L; Ribeiro dos Santos, A
- Crossed renal ectopy with fusionPublication . Cabral-Ribeiro, J; Pérez García, D; Leite, C; Ribeiro dos Santos, A