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- Orolingual angioedema after thrombolysis is not associated with insular cortex ischemia on pre-thrombolysis CTPublication . Pinho, J; Alves, JN; Oliveira, L; Pereira, S; Barros, JN; Machado, C; Amorim, JM; Santos, AF; Ribeiro, M; Ferreira, COrolingual angioedema (OA) is a well known early complication of treatment with alteplase in ischemic stroke patients. Our aim was to study risk factors for OA in these patients, namely insular cortex ischemia.