Browsing by Issue Date, starting with "2017-03"
Now showing 1 - 6 of 6
Results Per Page
Sort Options
- Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission?Publication . Macedo, F; Ladeira, K; Longatto-Filho, A; Martins, SFGastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this work was to review the angiogenic biomarkers related to the behavior of GC, documented in the literature. A search of the PubMed database was conducted with the MeSH terms: "Stomach neoplasms/blood [MeSH] or stomach neoplasms/blood supply [MeSH] and angiogenic proteins/blood [Major]". A total of 30 articles were initially collected, and 4 were subsequently excluded. Among the 26 articles collected, 16 examined the role of vascular endothelial growth factor (VEGF), 4 studied endostatin, 3 investigated angiopoietin (Ang)-2, 2 studied the Ang-like protein 2 (ANGTPL2), and 1 each examined interleukin (IL)-12, IL-8, and hypoxia inducible factor. Regarding VEGF, 6 articles concluded that the protein was related to lymph node metastasis or distant metastases. Five articles concluded that VEGF levels were elevated in the presence of GC and decreased following tumor regression, suggesting that VEGF levels could be a predictor of recurrence. Four articles concluded that high VEGF levels were correlated with poor prognosis and lower survival rates. Ang-2 and ANGTPL2 were elevated in GC and associated with more aggressive disease. Endostatin was associated with intestinal GC. VEGF is the most extensively studied angiogenic factor. It is associated with the presence of neoplastic disease and lymph node metastasis. It appears to be a good biomarker for disease progression and remission, but not for diagnosis. The data regarding other biomarkers are inconclusive.
- Superior mesenteric artery syndrome in a young womanPublication . Oliveira, CA; Barbosa, L; Dionísio, T
- Cannabis arteritis: ever more important to considerPublication . Santos, RP; Resende, C; Vieira, AP; Brito, CCannabis arteritis (CA) is a major and underdiagnosed cause of peripheral arterial disease in young patients. A 34-year-old man, daily smoker of 20 cigarettes and two cannabis cigarettes for 14 years, presented with a necrotic plaque of left hallux for 3 weeks. The Doppler ultrasound and angiography were compatible with severe Buerger's disease. Submitted to a revascularisation procedure and hypocoagulation with rivaroxaban. He had ceased smoking but maintained consumption of cannabis. Owing to the persistence of distal necrosis, amputation of the hallux was performed with good evolution. CA is a subtype of Buerger's disease. It is poorly known but increasingly prevalent and manifests in cannabis users regardless of tobacco use. The drug is considered at least a cofactor of the arteriopathy. The most effective treatment is cessation of consumption. Being cannabis one of the most consumed drugs, its mandatory to ask about its use in all young patients with arteriopathy.
- Warm hands but cold feetPublication . Arantes, C; Marques, J; Ribeiro, S; Quina-Rodrigues, C; Abreu, G; Rocha, S
- Therapeutic challenge of a paediatric case of Graves' disease with severe ophthalmopathyPublication . Ferreira, C; Meireles, C; Marques, O; Antunes, A
- Predictive Value of the SYNTAX Score in Culprit and Nonculprit Vessel Disease. ResponsePublication . Galvão-Braga, C; Cid-Álvarez, AB; Redondo Diéguez, A; Trillo-Nouche, R