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- Generalized bullous fixed drug eruption due to ibuprofenPublication . Almeida, FT; Caldas, R; Oliveira, ÁA; Pardal, J; Pereira, T; Brito, CIbuprofen can cause a wide variety of cutaneous reactions with a relatively high frequency, but establishing the causal relationship is usually difficult [1]. We report a case of a skin drug reaction due to ibuprofen, confirmed by positive patch test results.