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- The role of endoscopic ultrasound in a case of lung cancer with jaundicePublication . Castro-Pocas, FM; Araújo, TP; Ferreira, ML; Saraiva, MMLung cancer is one of the major causes of death in the world. Small cell carcinoma is the most aggressive type and can spread rapidly. The association of a small cell carcinoma with hepatic hilar metastasis and biliary obstruction is rare. Endoscopic ultrasound allows the aspiration of a cytology sample from adenopathies for diagnostic purpose. We present the case of a patient with lung cancer, with lymph node metastasis to the hepatic hilum and extrinsic biliary tree compression. Endoscopic ultrasound allowed the definitive diagnosis of hepatic hilar metastasis of a lung small cell carcinoma. To the author's knowledge it was the first time that endoscopic ultrasound was used for the diagnosis of hepatic hilar lymph node metastasis of lung cancer.
- Metastatic small bowel occlusion as initial presentation of squamous cell carcinoma of the lungPublication . Costa, RS; Vieira, AL; Costa, JM; Fernandes, B; Ferreira, A
- Pulmonary aspergillomas management: A 26-years case series of surgical therapyPublication . Vieira, AL; Fernandes, P; Lareiro, S; Guerra, M; Miranda, J; Vouga, L
- Tuberculosis incidence rate among the homeless population: The impact of socio-demographic and health-related variablesPublication . Vieira, AL; Oliveira, O; Gomes, M; Gaio, R; Duarte, R
- The role of Bronchoalveolar lavage in Interstitial Lung DiseasesPublication . Costa E Silva, M; Rolo, R
- Tuberculous Spondylitis: A Report of Different Clinical Scenarios and Literature UpdatePublication . Lacerda, CM; Linhas, R; Duarte, RTuberculosis is still one of the most important health problems in the world. In developed countries, the proportion of extrapulmonary tuberculosis cases is increasing. Nowadays tuberculous spondylitis, also known as Pott disease, is a rare clinical condition but can cause severe vertebral and neurological sequelae that can be prevented with an early correct diagnosis. The aim of this paper is to increase awareness of tuberculous spondylitis in modern times, describing three different cases and discussing its best diagnostic and therapeutic approach based on the current literature.
- Overall Survival Analysis and Characterization of an EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) PopulationPublication . Aguiar, F; Fernandes, G; Queiroga, H; Machado, JC; Cirnes, L; Souto Moura, C; Hespanhol, VBACKGROUND: Patients with activating somatic mutations in the Epidermal Growth Factor Receptor (EGFR) have better clinical outcomes when treated with Tyrosine Kinase Inhibitors (TKI) over chemotherapy. However, the impact of the use of TKIs on overall survival outside clinical trials is not well established. OBJECTIVE: To characterize and analyze the overall survival of a Caucasian population with NSCLC and EGFR mutations. METHODS: A retrospective cohort analysis of patients with NSCLC screened for EGFR mutations (exons 18-21) between October 2009 and July 2013 was conducted. Clinical and pathological characteristics, mutational EGFR status, treatment and overall survival were evaluated. RESULTS: From the 285 patients which performed screening for EGFR mutations, 54 (18.9%) had mutations, 25 (46.3%) of which in exon 19 and 20 of which (37.0%) in exon 21. The occurrence of mutations was associated with female sex and non-smoking habits (both, P<.001). The median survival of the global population was 12.0 months, with a better overall survival in mutated than non-mutated patients (20.0 vs 11.0 months, respectively; P=.007). CONCLUSION: These data contribute for a better knowledge of our lung cancer population concerning the mutational status and clinical outcomes, confirming a better overall survival for the patients with EGFR TKI sensible mutations.
- Cutaneous tuberculosis as metastatic tuberculous abscess.Publication . Pacheco, C; Silva, E; Miranda, J; Duarte, R
- Thoracic paraganglioma diagnosed in a patient with pulmonary tuberculosis - Case reportPublication . Cruz, JF; Iglésias, L; Monteiro, M; Santos, MJ; Pimentel, T; Silva, RP
- CT-guided transthoracic lung biopsy: Predictive factors of pneumothorax.Publication . Cruz, JF; Rolo, R; Iglésias, L; Cunha, J