The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer

Goulart, A; Ferreira, C; Rodrigues, A; Coimbra, B; Sousa, N; Leão, P

http://hdl.handle.net/10400.23/1330

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Abstract(s)

PURPOSE: Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear. This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC. METHODS: A prospective study of consecutive patients undergoing elective colorectal surgery during 1 year. Preoperative VEGF was determined by enzyme-linked immunosorbent assay and VEGF-R3 by immunochemistry. RESULTS: The initial sample included 134 patients with CRC diagnosis. Results showed significant association of serum values of VEGF with VEGF-R3 expression (P < 0.001), even in the presence of confounders (sex, age, body mass index, tumor location, and surgical approach). The estimated effect size was high (η2 = 0.35). CONCLUSION: Serum VEGF has a significant correlation with tumoral VEGF-R3 expression in CRC.

Keywords

Neoplasias Colorrectais Factores de Crescimento do Endotélio Vascular

URI

http://hdl.handle.net/10400.23/1330

Citation

Ann Surg Treat Res. 2019 Jul;97(1):15-20.

DOI

10.4174/astr.2019.97.1.15

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HB - CIR - Artigos

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