Publication
The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer
| dc.contributor.author | Goulart, A | |
| dc.contributor.author | Ferreira, C | |
| dc.contributor.author | Rodrigues, A | |
| dc.contributor.author | Coimbra, B | |
| dc.contributor.author | Sousa, N | |
| dc.contributor.author | Leão, P | |
| dc.date.accessioned | 2019-07-18T22:04:01Z | |
| dc.date.available | 2019-07-18T22:04:01Z | |
| dc.date.issued | 2019-07 | |
| dc.description.abstract | PURPOSE: Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear. This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC. METHODS: A prospective study of consecutive patients undergoing elective colorectal surgery during 1 year. Preoperative VEGF was determined by enzyme-linked immunosorbent assay and VEGF-R3 by immunochemistry. RESULTS: The initial sample included 134 patients with CRC diagnosis. Results showed significant association of serum values of VEGF with VEGF-R3 expression (P < 0.001), even in the presence of confounders (sex, age, body mass index, tumor location, and surgical approach). The estimated effect size was high (η2 = 0.35). CONCLUSION: Serum VEGF has a significant correlation with tumoral VEGF-R3 expression in CRC. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Ann Surg Treat Res. 2019 Jul;97(1):15-20. | pt_PT |
| dc.identifier.doi | 10.4174/astr.2019.97.1.15 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.23/1330 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Neoplasias Colorrectais | pt_PT |
| dc.subject | Factores de Crescimento do Endotélio Vascular | pt_PT |
| dc.title | The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 15-20 | pt_PT |
| oaire.citation.volume | 97 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |