Repository logo
 
Publication

The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma

2012Journal article Open access
Simple item page
dc.contributor.authorCarvalho, A
dc.contributor.authorCunha, C
dc.contributor.authorAlmeida, AJ
dc.contributor.authorOsório, NS
dc.contributor.authorSaraiva, M
dc.contributor.authorTeixeira-Coelho, M
dc.contributor.authorPedreiro, S
dc.contributor.authorTorrado, E
dc.contributor.authorDomingues, N
dc.contributor.authorGomes-Alves, AG
dc.contributor.authorMarques, A
dc.contributor.authorSilva MG
dc.contributor.authorLacerda, JF
dc.contributor.authorGomes, M
dc.contributor.authorPinto, AC
dc.contributor.authorTorres, F
dc.contributor.authorRendeiro, P
dc.contributor.authorTavares, P
dc.contributor.authorDi Ianni, M
dc.contributor.authorHeutink, P
dc.contributor.authorBracci, PM
dc.contributor.authorConde, L
dc.contributor.authorLudovico, P
dc.contributor.authorPedrosa, J
dc.contributor.authorMaciel, P
dc.contributor.authorPitzurra, L
dc.contributor.authorAversa, F
dc.contributor.authorMarques, H
dc.contributor.authorPaiva, A
dc.contributor.authorSkibola, CF
dc.contributor.authorRomani, L
dc.contributor.authorCastro, AG
dc.contributor.authorRodrigues, F
dc.date.accessioned2013-12-13T16:15:46Z
dc.date.available2013-12-13T16:15:46Z
dc.date.issued2012
dc.description.abstractNon-Hodgkin lymphoma (NHL) has been associated with immunological defects, chronic inflammatory and autoimmune conditions. Given the link between immune dysfunction and NHL, genetic variants in toll-like receptors (TLRs) have been regarded as potential predictive factors of susceptibility to NHL. Adequate anti-tumoral responses are known to depend on TLR9 function, such that the use of its synthetic ligand is being targeted as a therapeutic strategy. We investigated the association between the functional rs5743836 polymorphism in the TLR9 promoter and risk for B-cell NHL and its major subtypes in three independent case-control association studies from Portugal (1160 controls, 797 patients), Italy (468 controls, 494 patients) and the US (972 controls, 868 patients). We found that the rs5743836 polymorphism was significantly overtransmitted in both Portuguese (odds ratio (OR), 1.85; P=7.3E-9) and Italian (OR, 1.84; P=6.0E-5) and not in the US cohort of NHL patients. Moreover, the increased transcriptional activity of TLR9 in mononuclear cells from patients harboring rs5743836 further supports a functional effect of this polymorphism on NHL susceptibility in a population-dependent manner.por
dc.identifier.citationGenes Immun. 2012;13(2):197-201.por
dc.identifier.urihttp://hdl.handle.net/10400.23/565
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherNature Publishing Grouppor
dc.subjectLinfoma Não-Hodgkinpor
dc.subjectPolimorfismo Genéticopor
dc.subjectReceptor "Toll-Like" 9por
dc.titleThe rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphomapor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma.pdf
Size:
175.92 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.82 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

HB - IH - Artigos