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Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases

2014Journal article Open access
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dc.contributor.authorPacheco, C
dc.contributor.authorMorais, A
dc.contributor.authorRolo, R
dc.contributor.authorFerreira, L
dc.contributor.authorNabiço, R
dc.contributor.authorCunha, J
dc.date.accessioned2014-02-14T12:50:43Z
dc.date.available2014-02-14T12:50:43Z
dc.date.issued2014
dc.description.abstractINTRODUCTION: Chronic granulomatous disease associated with common variable immunodeficiency (GD-CVID), although well documented, is rare. Granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis. CLINICAL CASES: Case 1: A 39-year-old male patient with CVID, asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. GD-CVID was diagnosed by bone marrow biopsy. Progressive clinical and radiological improvement was obtained with corticotherapy. Case 2: A 38-year-old male patient with CVID, suffered from asthenia, anorexia, myalgia, lower limbs edemas, and dry cough. He had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. A spontaneous resolution was detected after 9 months of evolution. CONCLUSION: GD-CVID is rare and can mimetize other pathologies, namely, sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge.por
dc.identifier.citationRev Port Pneumol. 2014 Jan 22. pii: S0873-2159(13)00159-1.por
dc.identifier.urihttp://hdl.handle.net/10400.23/575
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSociedade Portuguesa de Pneumologiapor
dc.subjectDoença Granulomatosa Crónicapor
dc.subjectImunodeficiência de Variável Comumpor
dc.titleChronic granulomatous disease associated with common variable immunodeficiency - 2 clinical casespor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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