A carregar...
Publicação
Giant congenital melanocytic nevi and neurocutaneous melanosis
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 3.19 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient.
Descrição
Palavras-chave
Melanose/congénito Síndromes Neurocutâneas Nevo Pigmentado
Contexto Educativo
Citação
Case Rep Med. 2015;2015:545603.