Publication
Giant congenital melanocytic nevi and neurocutaneous melanosis
| dc.contributor.author | Araújo, C | |
| dc.contributor.author | Resende, C | |
| dc.contributor.author | Pardal, F | |
| dc.contributor.author | Brito, C | |
| dc.date.accessioned | 2015-03-27T10:51:29Z | |
| dc.date.available | 2015-03-27T10:51:29Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient. | por |
| dc.identifier.citation | Case Rep Med. 2015;2015:545603. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.23/842 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.subject | Melanose/congénito | por |
| dc.subject | Síndromes Neurocutâneas | por |
| dc.subject | Nevo Pigmentado | por |
| dc.title | Giant congenital melanocytic nevi and neurocutaneous melanosis | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |