HB - Neurologia
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Browsing HB - Neurologia by Author "Almeida, F"
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- From juvenile parkinsonism to encephalitis lethargica, a new phenotype of post-streptococcal disorders: case report.Publication . Beleza, P; Soares-Fernandes, J; Jordão, MJ; Almeida, FWe report the case of a 16-year-old boy presented with a mild akinetic-rigid parkinsonism shortly after a post-streptococcal infection. After stopping corticoids, he had a rapid neurological deterioration to a fatal encephalitis lethargica-like syndrome. Serum analysis demonstrated consistently elevated anti-streptolysin-O. This case illustrates a new severe phenotype in the spectrum of the post-streptococcal disorders. This etiology should be considered in the differential diagnosis of a movement disorder with a rapid detrimental evolution.
- IgE-mediated hypersensitivity after ibuprofen administrationPublication . Bluth, MH; Beleza, P; Hajee, F; Jordão, MJ; Figueiredo, J; Almeida, F; Smith-Norowitz, TAlthough many immunoglobulin-related drug sensitivities have been described, there is a paucity of reports regarding IgE-related drug sensitivities. Here we describe a case of a patient who demonstrated IgE-mediated sensitivity to ibuprofen.
- IgE-mediated hypersensitivity after ibuprofen administrationPublication . Bluth, MH; Beleza, P; Hajee, F; Jordão, MJ; Figueiredo, J; Almeida, F; Smith-Norowitz, TAlthough many immunoglobulin-related drug sensitivities have been described, there is a paucity of reports regarding IgE-related drug sensitivities. Here we describe a case of a patient who demonstrated IgE-mediated sensitivity to ibuprofen.
- Isolated oculomotor nerve paresis as the presenting sign of multiple sclerosisPublication . Beleza, P; Machado, A; Soares-Fernandes, J; Carneiro, G; Jordão, MJ; Almeida, F; Figueiredo, J
- Primary angiitis of the central nervous system: an infrequent form of presentationPublication . Jordão, MJ; Almeida, F; Moreira da Costa, JA; Rocha, JINTRODUCTION: Primary angiitis of the central nervous system (CNS) is a rare disease. Clinical signs and symptoms include headache and cognitive disorders associated to multifocal neurological deficits. A definitive diagnosis can only be achieved by means of a cerebromeningeal biopsy. CASE REPORT: We describe the case of a 15-year-old male who first reported lower back pain and progressive paresis of the right lower limb, later followed by laterocollis on the right side. Magnetic resonance (MR) scanning of the brain and spinal cord revealed a pseudotumoral lesion in the right cerebellum and two lesions in the spinal cord. Dexamethasone was administered and surgical resection of the cerebellar lesion was performed. Following surgery, the patient received corticoid treatment with progressive withdrawal. Full clinical recovery of the patient was achieved. A year later, the same patient was admitted to hospital again because of headaches and diplopia. A new MR brain scan showed a right frontotemporal lesion. Dexamethasone was administered and the patient recovered. Thirteen months later, he reported dysarthria and right-side hemiparesis. An MR brain scan revealed the presence of a number of bilateral lesions in the white matter. Results of a lumbar puncture showed lymphocytic pleocytosis and raised protein levels in cerebrospinal fluid. The laminae from the cerebromeningeal biopsy were reviewed and the results confirmed the hypothetical diagnosis of angiitis of the CNS. Treatment was established with intravenous cyclophosphamide in association with oral prednisone. CONCLUSIONS: Primary angiitis of the CNS is an infrequent disease and its pathogenesis remains unknown. The definitive diagnosis of these patients is histological. It courses spontaneously and generally has a fatal outcome. Treatment, which consists in an association of cyclophosphamide and prednisone, must be started as early as possible.
- Probable acute disseminated encephalomyelitis due to Haemophilus influenzae meningitisPublication . Beleza, P; Ribeiro, M; Pereira, J; Jordão, MJ; Almeida, FWe report the case of a 17-year-old male on long-term steroid therapy for minimal lesion glomerulopathy who, after an upper respiratory infection, presented with Haemophilus influenzae type b meningitis. Twenty-four hours later he developed depression of consciousness which progressed to coma and left hemiparesis. Brain magnetic resonance imaging (MRI) revealed multiple lesions (hyperintense on T2 and slightly hypointense on Tl) involving mainly white matter suggestive of inflammation. MRI features were compatible with acute disseminated encephalomyelitis (ADEM), although a differential diagnosis included cerebritis or vasculitis, secondary to bacterial meningitis. The patient was treated with high-dose steroids which resulted in a gradual improvement followed by complete clinical recovery. We propose a diagnosis of ADEM was the best diagnosis because of the radiological features and response to steroids. The occurrence of ADEM associated with acute meningitis, however rare, represents an important diagnostic challenge for the clinician.
- Reverse crossed cerebellar diaschisisPublication . Ribeiro, M; Beleza, P; Fernandes, J; Almeida, F; Rocha, JCerebral Magnetic Resonance imaging in acute postictal period is performed to exclude structural processes that can be responsible for the epileptic activity. Sometimes, the findings are the result of the epileptic activity, and not the cause reflecting the pathophysiologic changes during epileptic activity. In this paper we describe a patient with status epilepticus who has developed hemicerebellar involvement contralateral to a frontal epileptogenic focus. This phenomenon of Reverse Crossed Cerebellar Diaschisis is rare and has been describe only in Single Photon Emission Computed Tomography (SPECT).
- Takotsubo cardiomyopathy – a rare, but serious, complication of epileptic seizuresPublication . Rocha, J; Gonçalves, E; Vieira, C; Almeida, F; Pereira, JTakotsubo cardiomyopathy (TKC) is a reversible, yet potentially fatal, syndrome triggered by stressful conditions, including seizures, with increasing recognition in clinical practice. We report a TKC in a patient with unexplained sinus tachycardia and troponin elevation after generalized seizures.
- Takotsubo cardiomyopathy: a rare, but serious, complication of epileptic seizuresPublication . Rocha, J; Gonçalves, E; Vieira, C; Almeida, F; Pereira, J
- Wallerian degeneration after stroke: a new prognostic factor?Publication . Soares-Fernandes, J; Beleza, P; Ribeiro, M; Maré, R; Almeida, F; Rocha, JWallerian degeneration (WD) after ischemic stroke has been associated to persistent motor impairment, but signal intensity changes on conventional magnetic resonance imaging (MRI) are generally not detected until four weeks after the event. We report a 54 year old male patient, referred to our hospital for sudden-onset left hemiparesis. Cerebral CT showed right fronto-parietal infarct (middle cerebral artery stroke). We performed two CT control, which revealed no haemorrhagic transformation. MRI, obtained 13 days after the onset, demonstrated the infarct, mainly subcortical, extending throughout fronto-temporo-parietal areas and restricted diffusion in the ipsilateral corticospinal tract. In conclusion, WD is apparent on diffusion-weighted imaging within two weeks of stroke, allowing a better prognostic evaluation of recovery. The abnormal signal should not be misinterpreted as new ischaemic lesions.